Born in China, Guo began studying music at the age of three and pursued piano and composition studies at Interlochen Arts Academy, the Peabody Institute of the Johns Hopkins University and Rice University. She is currently a PhD candidate at UCLA studying composition under Richard Danielpour, Peter Golub, Ian Krouse and Kay Rhie.

Her previous composition teachers include Samuel Adler, Shih-hui Chen, Jason Eckardt, Michael Hersch, Pierre Jalbert, Amy Kirsten and Cynthia Van Mannen. She has also had various master classes with great composers such as James Newton Howard, Steven Stucky, Shulamit Ran, George Lewis and Christopher Rouse.

Her pieces have been read/performed by renowned soloists such as Miranda Cuckson, Courtney Orlando, Michael Kannen, Sarah Thornblade, Michael Kaufman, Jonathan Sacdalan, Bella Hristova, David Kaplan, Jihye Chang, Kyung Wha Chu and Stefano Greco. Her work has also been presented by ensembles such as IIIZ+, Deviant Septet, Texas New Music Ensemble and Winsor Music. Furthermore, her orchestra piece Night Ghost was performed by the Shepherd School Symphony Orchestra (conducted by Benjamin Manis) in 2019 and the Cleveland Institute of Music Orchestra (conducted by Shun Yao) in 2020.